Benefits of Milk Thistle: Side Effects & Uses Guide | OriGym.Prednisone and Milk thistle drug interactions, a phase IV clinical study of FDA data - eHealthMe
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Milk thistle and prednisone interaction. Prednisone and Milk thistle drug interactions - a phase IV clinical study of FDA data
Milk thistle and prednisone interaction.Benefits of Milk Thistle: Side Effects & Uses Guide
Milk thistle and prednisone interaction -
Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.
Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures. Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss.
Doctors can measure levels of activated vitamin D called 1,25 dihydroxycholecalciferol to determine whether a deficiency exists; if so, activated vitamin D is only available by prescription. A study of rheumatoid arthritis patients treated with low amounts of prednisone found that those who received 1, mg of calcium per day plus IU of vitamin D per day for two years experienced no bone loss during that time period.
An analysis of properly conducted trials concluded that supplementation with vitamin D and calcium was more effective than placebo or calcium alone in protecting against corticosteroid-induced osteoporosis. Most doctors recommend 1, mg of calcium and — IU vitamin D per day for the prevention of osteoporosis.
Preliminary data suggest that corticosteroid treatment increases chromium loss. Double-blind trials are needed to confirm these observations. In a preliminary trial, supplementation with a probiotic Lactobacillus GG reduced the frequency of severe diarrhea and the incidence of abdominal discomfort related to the use of 5-FU. The amount of Lactobacillus GG used was billion organisms per day during the 24 weeks of chemotherapy.
A controlled trial found that a single dose of the synthetic corticosteroid dexamethasone suppressed production of melatonin in nine of 11 healthy volunteers. Further research is needed to determine if long-term use of corticosteroids interferes in a meaningful way with melatonin production, and whether supplemental melatonin would be advisable for people taking corticosteroids. A modified form of vitamin A has been reported to work synergistically with chemotherapy in test tube research.
Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine NAC —all antioxidants—protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy.
A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with.
Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. Oral corticosteroids increase the urinary loss of potassium. This may not cause a significant problem for most people. Individuals who wish to increase potassium intake should eat more fruits, , and juices rather than taking over-the-counter potassium supplements, which do not contain significant amounts of potassium. Oral corticosteroids have been found to increase urinary loss of vitamin K , vitamin C , selenium , and zinc.
The importance of these losses is unknown. Patients with inoperable head and neck cancer were treated with a spleen peptide preparation Polyerga in a double-blind trial during chemotherapy with cisplatin and 5-FU.
The spleen preparation had a significant stabilizing effect on certain white blood cells. People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. Taurine has been shown to be depleted in people taking chemotherapy. It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements.
Corticosteroids may increase the loss of vitamin B6. One double-blind study of people with asthma failed to show any added benefit from taking mg per day of vitamin B6 along with inhaled steroids.
Therefore, while small amounts of vitamin B6 may be needed to prevent deficiency, large amounts may not provide added benefit. Some doctors recommend that people taking corticosteroids for longer than two weeks supplement with at least 2 mg of vitamin B6 per day.
Acetyl-L-carnitine in the amount of 1, mg three times per day for eight weeks has been shown to improve nerve damage neuropathy caused by the chemotherapy drug cisplatin.
Preliminary data suggest that supplementation with chromium mcg per day in the form of chromium picolinate may prevent corticosteroid-induced diabetes. Ginger Zingiber officinale can be helpful in alleviating nausea and vomiting caused by chemotherapy.
In a study in the Journal of Diabetes Research , researchers found that giving patients with diabetes silymarin alongside their traditional treatments actually reduced fasting blood sugar levels.
Did you know that the benefits of blueberries also includes helping regulate diabetes? Milk thistle has also been proven to lower cholesterol, which can have a positive impact on regulating diabetes. Additionally, it is believed that the anti-inflammatory and antioxidant properties of milk thistle can be useful in reducing any risk of developing diabetic complications such as kidney disease!
You must speak to your GP before trying milk thistle supplements if you have diabetes. Amyloid plaques are clusters of sticky amyloid proteins which build up between nerve cells as you get older.
They can also build up in the blood vessels too, which can restrict the amount of blood that gets to the brain. Not enough blood reaching the brain could ultimately result in a stroke. Not only can you use milk thistle for liver problems or regulating diabetes, but you can also use it to keep your skin healthy and treat acne. Acne is an inflammatory skin condition. One of the reasons that excess sebum is created is due to excess hormonal activity. Acne has also been suggested to be caused by oxidative stress, which milk thistle is the perfect combatant for.
Due to its anti-inflammatory and anti-oxidative properties, milk thistle can be a useful supplement for treating acne. Your liver plays an important role in balancing your hormones, as it removes compounds that have accumulated in the body, such as hormones.
Milk thistle can help your liver flush out any toxins that have been hanging around, which in turn can help purify and cleanse the skin! Repeat this for a few weeks and you could see a difference in the health of your skin.
If you regularly suffer from stomach issues such as bloating, gas, and indigestion, milk thistle could help you there too. Bloating can be caused by a multitude of things, such as constipation and irritable bowel syndrome, but it's mainly caused by food intolerance and eating foods that make you gassy. One again, the liver plays an important role in digestion, just as it does with helping keep your skin healthy.
The liver produces bile, which is needed for digestion and absorption of fat-soluble vitamins, such as Vitamins A, D, E, and K. Taking milk thistle tablets can help alleviate the symptoms of an upset stomach or indigestion. When to take milk thistle for these problems is dependent on what the brand of tablets tell you, but typically 30 minutes before a meal, whilst on an empty stomach, is generally seen as the best time to take them.
You can buy a milk thistle supplement from all good drug stores and online, even on websites such as Amazon. Another food that's great for aiding digestion is the eggplant. Read through our article to find out the other benefits of eggplant and why you should be eating it.
Anyone who drinks alcohol will probably have experienced a hangover the morning after a heavy night out and will know how horrible they are. Hangovers are caused by your blood alcohol level returning to zero, which in turn causes symptoms such as headaches, upset stomachs, dry mouth, fatigue, and sensitivity to light. It can also affect your sleep and trigger mild dehydration.
Toxic byproducts left behind when your body breaks down alcohol can cause inflammation throughout your body, especially in the stomach, brain, and liver. Over time, the inflammation on the liver can irreversibly scar it, causing cirrhosis, which could lead to poor liver function. It is suggested that silymarin may be able to detoxify some of the more harmful compounds in alcohol, protecting your liver in the process. Another one of the milk thistle health benefits is supporting weight loss, thanks to its ability to help detoxify the liver and help to reduce your blood sugar levels.
In some animal research, mice were fed a high fat diet that was intended to make them put on weight. In fact, they lost weight. Whilst more human research is needed, this is a promising start. As we already know, milk thistle helps balance your blood sugar levels, which has an effect on how milk thistle benefits weight loss.
Having a stable blood sugar level will also mean that you will feel fuller for longer, once again reducing the need to snack. Another point we already know is that milk thistle and the silymarin found in it helps you digest your food better.
When you digest efficiently, your liver is able to eliminate toxins more efficiently, meaning your body is able to metabolise fat better. Reply Share. Delete Reply. Note Required. Cancel Confirm. Read carefully Block Member.
Are you sure you want to block this member? Milk thistle By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Milk thistle. National Center for Complementary and Integrative Health. Accessed Oct. IBM Micromedex. Natural Medicines. Pizzorono JE, et al. Silybum marianum milk thistle. In: Textbook of Natural Medicine.
The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels. Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures. Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.
Oral corticosteroids reduce absorption of calcium and interfere with the activation and metabolism of the vitamin, increasing the risk of bone loss. Doctors can measure levels of activated vitamin D called 1,25 dihydroxycholecalciferol to determine whether a deficiency exists; if so, activated vitamin D is only available by prescription.
A study of rheumatoid arthritis patients treated with low amounts of prednisone found that those who received 1, mg of calcium per day plus IU of vitamin D per day for two years experienced no bone loss during that time period. An analysis of properly conducted trials concluded that supplementation with vitamin D and calcium was more effective than placebo or calcium alone in protecting against corticosteroid-induced osteoporosis.
Most doctors recommend 1, mg of calcium and — IU vitamin D per day for the prevention of osteoporosis. Preliminary data suggest that corticosteroid treatment increases chromium loss. Double-blind trials are needed to confirm these observations. In a preliminary trial, supplementation with a probiotic Lactobacillus GG reduced the frequency of severe diarrhea and the incidence of abdominal discomfort related to the use of 5-FU.
The amount of Lactobacillus GG used was billion organisms per day during the 24 weeks of chemotherapy. A controlled trial found that a single dose of the synthetic corticosteroid dexamethasone suppressed production of melatonin in nine of 11 healthy volunteers. Further research is needed to determine if long-term use of corticosteroids interferes in a meaningful way with melatonin production, and whether supplemental melatonin would be advisable for people taking corticosteroids. A modified form of vitamin A has been reported to work synergistically with chemotherapy in test tube research.
Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. In a double-blind study, Japanese researchers found that the combination of vitamin Evitamin C, and N-acetyl cysteine NAC —all antioxidants—protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with.
Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. Oral corticosteroids increase the urinary loss of potassium. This may not cause a significant problem for most people. Individuals who wish to increase potassium intake should eat more fruits,and juices rather than taking over-the-counter potassium supplements, which do not contain significant amounts of potassium.
Oral corticosteroids have been found to increase urinary loss of vitamin Kvitamin Cseleniumand zinc. The importance of these losses is unknown.
Patients with inoperable head and neck cancer were treated with a spleen peptide preparation Polyerga in a double-blind trial during chemotherapy with cisplatin and 5-FU. The spleen preparation had a significant stabilizing effect on certain white blood cells. People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. Taurine has been shown to be depleted in people taking chemotherapy.
It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. Corticosteroids may increase the loss of vitamin B6. One double-blind study of people with asthma failed to show any added benefit from taking mg per day of vitamin B6 along with inhaled steroids. Therefore, while small amounts of vitamin B6 may be needed to prevent deficiency, large amounts may not provide added benefit. Some doctors recommend that people taking corticosteroids for longer than two weeks supplement with at least 2 mg of vitamin B6 per day.
Acetyl-L-carnitine in the amount of 1, mg three times per day for eight weeks has been shown to improve nerve damage neuropathy caused by the chemotherapy drug cisplatin.
Preliminary data suggest that supplementation with chromium mcg per day in the form of chromium picolinate may prevent corticosteroid-induced diabetes. Ginger Zingiber officinale can be helpful in alleviating nausea and vomiting caused by chemotherapy.
Ginger, as tablets, capsules, or liquid herbal extracts, can be taken in mg amounts every two or three hours, for a total of 1 gram per day. Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy.
In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans.
Glutamine has successfully reduced chemotherapy-induced mouth sores. In one trial, people were given 4 grams of glutamine in an oral rinse, which was swished around the mouth and then swallowed twice per day. Thirteen of fourteen people in the study had fewer days with mouth sores as a result. These excellent results have been duplicated in some, but not all double-blind research. In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.
One double-blind trial suggested that 6 grams of glutamine taken three times per day can decrease diarrhea caused by chemotherapy. However, other studies using higher amounts or intravenous glutamine have not reported this effect. In a double-blind study, supplementation with 18 grams of glutamine per day for 15 days, starting five days before the beginning of 5-FU therapy, significantly reduced the severity of drug-induced intestinal toxicity.
High-dose cisplatin chemotherapy is associated with kidney toxicity and damage, which may be reduced by glutathione administration. Nerve damage is another frequent complication of high amounts of cisplatin. There is no evidence that glutathione taken by mouth has the same benefits. Melatonin supplementation 20 mg per day has decreased toxicity and improved effectiveness of chemotherapy with cisplatin plus etoposide and cisplatin plus 5-FU.
A common side effect of antibiotics is diarrheawhich may be caused by the elimination of beneficial bacteria normally found in the colon. Controlled studies have shown that taking probiotic microorganisms—such as Lactobacillus caseiLactobacillus acidophilusBifidobacterium longumor Saccharomyces boulardii —helps prevent antibiotic-induced diarrhea. The diarrhea experienced by some people who take antibiotics also might be due to an overgrowth of the bacterium Clostridium difficilewhich causes a disease known as pseudomembranous colitis.
Controlled studies have shown that Lactobacillus acidophilus might prevent candida vaginitis. In one human study, administration of 4, mcg per day of a selenium product, Seleno-Kappacarrageenan, reduced the kidney damage and white blood cell—lowering effects of the chemotherapy drug cisplatin. The amount of selenium used in this study is potentially toxic and should only be used under the supervision of a doctor. In another study, patients being treated with cisplatin and cyclophosphamide for ovarian cancer were given a multivitamin preparation, with or without mcg of selenium per day.
Compared with the group not receiving selenium, those receiving selenium had a smaller reduction in white blood cell count and fewer chemotherapy side effects such as nausea, hair loss, weakness, and loss of appetite. In a preliminary trial, taking wheat grass in the amount of 60 ml about 2 ounces per day during chemotherapy reduced the incidence of certain chemotherapy-related side effects including anemia and a decline in white blood cell counts in women with breast cancer.
Taking wheat grass did not appear to interfere with the anticancer effect of the chemotherapy. The chemotherapy used in this study was a combination of 5-fluorouracil, doxorubicin, and cyclophosphamide. In one study, taking mg of Saccharomyces boulardii twice daily enhanced the effectiveness of the antibiotic vancomycin in preventing recurrent clostridium infection. Therefore, people taking antibiotics who later develop diarrhea might benefit from supplementing with saccharomyces organisms.
According to preliminary human studies, horny goat weed offset some of the side effects of corticosteroids. Silymarin also offsets the kidney toxicity of cisplatin in animals. Silymarin has not yet been studied in humans treated with cisplatin.
There is some evidence that silymarin may not interfere with some chemotherapy in humans with cancer. Peptides or short proteins derived from the thymus gland, an important immune organ, have been used in conjunction with chemotherapy drugs for people with cancer. One study using thymosin fraction V in combination with chemotherapy, compared with chemotherapy alone, found significantly longer survival times in the thymosin fraction V group.
A related substance, thymostimulin, decreased some side effects of chemotherapy and increased survival time compared with chemotherapy alone. A third product, thymic extract TP1, was shown to improve immune function in people treated with chemotherapy compared with effects of chemotherapy alone. Thymic peptides need to be administered by injection.
People interested in their combined use with chemotherapy should consult a doctor. One preliminary study found that in people with fibrosing alveolitis a rare lung diseasesupplementation with mg N-acetyl cysteine three times per day increased the effectiveness of prednisone therapy. Oral corticosteroids cause both sodium and water retention.
People taking corticosteroids should talk with their doctor about whether they should restrict salt intake. Licorice Glycyrrhiza glabra extract was shown to decrease the elimination of prednisone in test tube studies. If this action happens in people, it might prolong prednisone activity and possibly increase prednisone-related side effects.
A small, controlled study found that intravenous iv glycyrrhizin an active constituent in liquorice given with iv prednisolone prolonged prednisolone action in healthy men. Whether this effect would occur with oral corticosteroids and liquorice supplements is unknown.
An animal study has shown that glycyrrhizin prevents the immune-suppressing actions of cortisone—the natural corticosteroid hormone produced by the body. More research is necessary to determine if this action is significant in humans taking oral corticosteroids.
Until more is known, people should not take liquorice with corticosteroids without first consulting a doctor. A controlled French trial reported that when postmenopausal late-stage breast cancer patients were given very large amounts of vitamin A ,—, IU per day along with chemotherapy, remission rates were significantly better than when the chemotherapy was not accompanied by vitamin A.
Similar results were not found in premenopausal women. The large amounts of vitamin A used in the study are toxic and require clinical supervision. Use of buckthorn Rhamnus catartica, Rhamnus frangula, Frangula alnus or alder buckthorn Rhamnus catarticaRhamnus frangulafor more than ten days consecutively may cause a loss of electrolytes especially the mineral potassium. Because corticosteroids also cause potassium loss, buckthorn or alder buckthorn should be used with caution if corticosteroids are being taken.
Chemotherapy can injure cancer cells by creating oxidative damage. As a result, some oncologists recommend that patients avoid supplementing antioxidants if they are undergoing chemotherapy. Limited test tube research occasionally does support the idea that an antioxidant can interfere with oxidative damage to cancer cells.
However, most scientific research does not support this supposition. A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but neither does it show that antioxidants should be avoided for fear that the actions of chemotherapy are interfered with. Echinacea is a popular immune-boosting herb that has been investigated for use with chemotherapy. One study investigated the actions of cyclophosphamideechinacea, and thymus gland extracts to treat advanced cancer patients.
Although small and uncontrolled, this trial suggested that the combination modestly extended the life span of some patients with inoperable cancers.
Drug interactions are reported among people who take Prednisone and Milk thistle. Common interactions include drug effect decreased among females and. 4 drugs are known to interact with milk thistle. Does Milk Thistle Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional . 4 drugs are known to interact with milk thistle. Given milk thistle's action on the liver, the stie of most drug metabolism, it would be wise to speak to your doctor if you are taking any medication before. Taking the oral corticosteroid methylprednisolone with grapefruit juice has been shown to delay the absorption and increase the blood concentration of the drug. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist. The phase IV clinical study analyzes what interactions people who take Prednisone and Milk thistle have. Bodybuilders who take steroids, for example, can put the liver under considerable stress and damage cells. Acetyl-L-carnitine in the amount of 1, mg three times per day for eight weeks has been shown to improve nerve damage neuropathy caused by the chemotherapy drug cisplatin. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Silymarin also offsets the kidney toxicity of cisplatin in animals.Drug interactions are reported among people who take Prednisone and Milk thistle. Common interactions include drug effect decreased among females and fatigue among males.
The phase IV clinical study analyzes what interactions people who take Prednisone and Milk thistle have. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. Milk thistle has active ingredients of milk thistle. It is often used in fatty liver.
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. The study uses data from the FDA. It is based on prednisone and milk thistle the active ingredients of Prednisone and Milk thistle, respectively , and Prednisone and Milk thistle the brand names.
Other drugs that have the same active ingredients e. Dosage of drugs is not considered in the study. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5, more each day. Our analysis results are available to researchers, health care professionals, patients testimonials , and software developers open API. All information is observation-only.
Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect.
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