Looking for: Clobetasol propionate cream vs betamethasone.Clobetasol Click here Clobetasol propionate cream vs betamethasone Back to Medicines A to Z. Clobetasol propionate is a medicine that's used on the skin to treat swelling, itching and irritation. It can help with skin problems such as:. Clobetasol is available on prescription only. There is also a cream and ointment called clobetasone which sounds similar to clobetasol. Clobetasone is much milder and you can buy it from pharmacies or supermarkets. Clobetasol may not be suitable for some people. Tell a pharmacist or doctor before taking it if you:. Always follow the instructions from a pharmacist, doctor or leaflet in the medicine packet. Most people only need to use clobetasol 1 or 2 times a day for 1 week. A doctor may suggest that you use it for longer than 1 week. If you use it 2 times a day, try to leave a gap of 8 to 12 hours after using it. If it's been prescribed for your child und...